I have written an article published in the February 2019 issue of PCLinuxOS Magazine on this topic. Since then, the official ImageScan Version 3 utility from Epson's website is now in the testing section of the PCLinuxOS repository.
While it does work on PCLinuxOS (I have tested this myself), it will not work with the GIMP as it was not implemented as a GIMP plugin. This can be installed alongside the epkowa driver supplied with the iscan package. My thanks to AnalogueMan for requesting the driver to be included in the PCLinuxOS repository.
About Version 2 of Epson's Image Scan! for Linux
What I was getting at was that Version 2 of Epson's Image Scan! for Linux (which actually works with the GIMP) includes an epkowa driver that is newer than the version supplied with the iscan package (which does not include the Epson created scanning utility.
This package is a compressed tarball (.tar.gz) file that should be unpacked in an empty directory. Once unpacked, there are three directories and a ./install.sh script (obviously for installation of the RPM files).
This script will not work with PCLinuxOS unless you do not have the iscan package from the repository installed because some of the files in the RPM packages cause a conflict with some of the files in the iscan package that is in the repository.
First, Setup Your Hardware First
Before you configure your new Epson printer, you should setup the printer itself according to the directions supplied by the Quick Start guide, until you get to the part where the software is to be installed from the supplied CD (if there is one).
For PCLinuxOS (and Slackware as well), you will not need the supplied CD.
Usually, this means removing any packing tape used to secure delicate parts when the printer was in transit from the factory to the store where you purchased your printer. This is followed then by plugging in the power cord, then powering up the printer, followed by insertion of the supplied ink cartridges.
Newer Epson printers have Wi-Fi capability built in to the device. Before you connect the printer to a Wi-Fi router, make sure that the security on that router has not been compromised. For best results, connect to a Wi-Fi network that is protected with WPA2-PSK encription (with the AES option enabled). This is currently the most secure form of network encryption available for home use.
Once you have the printer powered up and (optionally) connected, you may then setup the printer according to the instructions in my article at PCLinuxOS Magazine.